Common symptoms of PNH include:
Chronic severe fatigue
Dark/unusually coloured urine
Lack of mental clarity – forgetfulness, difficulty concentrating
Tingling or numbness, particularly in the extremities
Shortness of breath
Loss of appetite
Oesophageal (gullet) pain
Arrhythmia (irregular heartbeat)
Difficulty dealing with daily tasks and situations
Lack of motivation
Patients may experience few or many of the above symptoms, as well as other less common symptoms. The progress of PNH cannot be predicted and when prescribing best possible treatment, your doctor should take into account your medical history, lifestyle and personal situation as well as the risks and benefits of each treatment.
Many of these symptoms are related to haemolysis. Please click here for further information about haemolysis and common triggers.