|Bacterial or viral infections||Lack of sleep|
|Certain foods, usually those containing high levels of fat||Alcohol|
|Other illnesses, injuries or surgery||Flying|
Chronic haemolysis places continuous strain on vital organs, particularly the liver; kidneys; and heart, thus increasing the risk of serious and life-threatening complications such as liver and/or kidney failure; heart attack; stroke; deep vein thrombosis; Budd-Chiari Syndrome (a clot or clots in the hepatic vein of the liver); or blood clots in other veins or organs.
Clots are the most common complication of PNH and the leading cause of death among patients. This is a scary thing for a patient to face, but knowing the signs and symptoms of a clot and getting treatment as soon as possible can minimise the risk of further complication. If you experience swelling in the limbs or abdomen and severe and/or sudden onset of pain, you should seek medical advice immediately.