Common symptoms of PNH include:

Anaemia

Chronic severe fatigue

Jaundice

Nausea

Abdominal pain

Muscular pain

Joint pain

Dark/unusually coloured urine

Lack of mental clarity – forgetfulness, difficulty concentrating

Insomnia

Tingling or numbness, particularly in the extremities

Shortness of breath

Headaches

Dizziness

Loss of appetite

Oesophageal (gullet) pain

Erectile dysfunction

Arrhythmia (irregular heartbeat)

Difficulty dealing with daily tasks and situations

Digestive problems

Lack of motivation

Patients may experience few or many of the above symptoms, as well as other less common symptoms. The progress of PNH cannot be predicted and when prescribing best possible treatment, your doctor should take into account your medical history, lifestyle and personal situation as well as the risks and benefits of each treatment.

Many of these symptoms are related to haemolysis. Please click here for further information about haemolysis and common triggers.